CURRENT RESEARCH PROJECTS
- Organocatalysis using BrØnsted bases, amino acid derivatives, cyclic amine derivatives, cinchonda alkaloids, and bifunctional organic molecules
- Organic reactive intermediates and unusual molecules
- Weaker intermolecular interactions, include CH/p, p/p and cation/p interactions, halogen bond
- Supramolecular chemistry and molecular recognition
- Design of novel molecular sensors for cations and anions
- Colorimetric and fluorescent sensing
- Hydrogen storage materials
- Sulfur chemistry, sulfur clusters, chiral phosphides
- Radical reactions in chemistry and biology
- Transition-metal catalysis, rhenium and chromium complexes
- Applications of surface enhanced Raman spectroscopy (SERS) and terahertz spectroscopy
- Computer-aided drug design and molecular docking
REPRESENTATIVE PUBLICATIONS
(1) "Oxyanion Hole Stabilization by CH∙∙∙O Interaction in a Transition State - A Three-Point Interaction Model for Cinchona Alkaloid-Catalyzed Asymmetric Methanolysis of Meso-Cyclic Anhydrides", H. Yang and M.W. Wong, J. Am. Chem. Soc. 2013, 135, 5808.
(2) "Origin of Asymmetric Induction in Bicyclic Guanidine-Catalyzed Thio-Michael Reaction: A Bifunctional Mode of Lewis and Brønsted Acid Activations", B. Cho, C.-H. Tan, and M.W. Wong, J. Org. Chem.2012, 77, 6553-6562.
(3) "Selenium Blue-alpha and -beta: Turning on the fluorescence of a Pyrenyl Fluorophore via Oxidative Cleavage of the Se-C Bond by Reactive Oxygen Species", W. Chen, B. P. Bay, M.W. Wong, and D.J. Huang, Tetrahedron Lett. 2012, 253, 3843.
(4) "Mechanistic Investigation on the Formation and Dehydrogenation of Calcium Amidoborane Ammoniate", Y.S. Chua, W. Li, W.J. Shaw, G.T. Wu, T. Autrey, Z. Xiong, M.W. Wong, and P. Chen, ChemSusChem 2012, 5, 927-931.
(5) "Computational Design of Thiourea-based Cyclophane Anion Sensors", H. Xie and M.W. Wong, Aust. J. Chem. 2012, 65, 303-313.
(6) "beta-Amino Acid-Catalyzed Asymmetric Michael Additions: Design of Organocatalysts with Catalytic Acid/Base Dyad Inspired by Serine Proteases", H. Yang and M.W. Wong, J. Org. Chem. 2011, 76, 7399.
(7) "Synthesis of a Chiral Quaternary Carbon Center Bearing a Fluorine Atom: Enantioselective and Diastereoselective Guanidine-Catalyzed Addition of Fluorocarbon Nucleophiles", Z. Jiang, Y. Pan, Y. Zhao, T. Ma, R. Lee, Y. Yang, K.-W. Huang, M.W. Wong and C.-H. Tan, Angew. Chem. Int. Ed. 2009, 48, 3627.
(8) "Dark-Red O8 Molecules in Solid Oxygen: Rhomboid Clusters, Not S8-Like Rings", R. Steudel and M.W. Wong, Angew. Chem. Int. Ed. 2007, 46, 1768.
(9) "Complex formation of the Vulcanization Accelerator Tetramethyldiuram Disulfide (TMTD) and Related Molecules with Various Zinc Compounds Including Zinc Oxide Clusters (Zn4O4)", R. Steudel, Y. Steudel and M.W. Wong, Chem. Eur. J. 2008, 14, 919.
(10) "Mechanism of Metal Halide-Promoted Mukaiyama Aldol Reactions", C.T. Wong and M.W. Wong, J. Org. Chem. 2007, 72, 1425.
(11) "Reaction of the Radical Pair NO2• and CO3•– on 2-[6-(4′-Amino)phenoxy-3H-xanthen-3-on- 9-yl]benzoic Acid (APF)", A.M. Mak, M. Whiteman and M.W. Wong, J. Phys. Chem. A, 2007, 111, 8202.
(12) "Structures and Vibrational Spectra of the Sulfur-Rich Oxides SnO (n = 4-9). The Importance of p*-p* Interaction", M.W. Wong, Y. Steudel and R. Steudel, Chem. Eur. J. 2007, 13, 502.
(13) "Saturated Hydrocarbon-Benzene Complexes: A Theoretical Study of Cooperative CH/p Interaction", Ran J. and M.W. Wong, J. Phys. Chem. A 2006, 110, 9702.
(14) "Structures of the Trisulfur Oxides S3O and S3O+: Branched Rings, not Open Chains", M.W. Wong and R. Steudel, Chem. Commun. 2005, 3712.
(15) "On the Roles of C-H….O=S and p-stacking Interactions in 2-Bromoacrolein Complex with N-tosyl-(S)-tryptophan Derived Oxazaborolidinone Catalyst", M.W. Wong, J. Org. Chem. 2005, 70, 5487.
(16) "Fluoride Ion Receptors Based on Dipyrrolyl Derivatives Bearing Electron-Withdrawing Groups: Synthesis, Optical and Electrochemical Sensing and Computational studies", T. Ghosh, B.G. Maiya, and M.W. Wong, J. Phys. Chem. A 2004, 108, 11249.
(17) "Quantum-Chemical Calculations of Sulfur-Rich Compounds", M.W. Wong, Top. Curr. Chem. 2003,231, 1.
(18) "Atomic Properties of N2O4 Based on Its Experimental Charge Density", M. Messerschmidt, A. Wagner, M.W. Wong, and P. Luger, J. Am. Chem. Soc. 2002, 124, 732.
(19) "Prediction of a Metastable Helium Compound: HHeF", M.W. Wong, J. Am. Chem. Soc. 2000, 122, 6289.
(1) "Oxyanion Hole Stabilization by CH∙∙∙O Interaction in a Transition State - A Three-Point Interaction Model for Cinchona Alkaloid-Catalyzed Asymmetric Methanolysis of Meso-Cyclic Anhydrides", H. Yang and M.W. Wong, J. Am. Chem. Soc. 2013, 135, 5808.
(2) "Origin of Asymmetric Induction in Bicyclic Guanidine-Catalyzed Thio-Michael Reaction: A Bifunctional Mode of Lewis and Brønsted Acid Activations", B. Cho, C.-H. Tan, and M.W. Wong, J. Org. Chem.2012, 77, 6553-6562.
(3) "Selenium Blue-alpha and -beta: Turning on the fluorescence of a Pyrenyl Fluorophore via Oxidative Cleavage of the Se-C Bond by Reactive Oxygen Species", W. Chen, B. P. Bay, M.W. Wong, and D.J. Huang, Tetrahedron Lett. 2012, 253, 3843.
(4) "Mechanistic Investigation on the Formation and Dehydrogenation of Calcium Amidoborane Ammoniate", Y.S. Chua, W. Li, W.J. Shaw, G.T. Wu, T. Autrey, Z. Xiong, M.W. Wong, and P. Chen, ChemSusChem 2012, 5, 927-931.
(5) "Computational Design of Thiourea-based Cyclophane Anion Sensors", H. Xie and M.W. Wong, Aust. J. Chem. 2012, 65, 303-313.
(6) "beta-Amino Acid-Catalyzed Asymmetric Michael Additions: Design of Organocatalysts with Catalytic Acid/Base Dyad Inspired by Serine Proteases", H. Yang and M.W. Wong, J. Org. Chem. 2011, 76, 7399.
(7) "Synthesis of a Chiral Quaternary Carbon Center Bearing a Fluorine Atom: Enantioselective and Diastereoselective Guanidine-Catalyzed Addition of Fluorocarbon Nucleophiles", Z. Jiang, Y. Pan, Y. Zhao, T. Ma, R. Lee, Y. Yang, K.-W. Huang, M.W. Wong and C.-H. Tan, Angew. Chem. Int. Ed. 2009, 48, 3627.
(8) "Dark-Red O8 Molecules in Solid Oxygen: Rhomboid Clusters, Not S8-Like Rings", R. Steudel and M.W. Wong, Angew. Chem. Int. Ed. 2007, 46, 1768.
(9) "Complex formation of the Vulcanization Accelerator Tetramethyldiuram Disulfide (TMTD) and Related Molecules with Various Zinc Compounds Including Zinc Oxide Clusters (Zn4O4)", R. Steudel, Y. Steudel and M.W. Wong, Chem. Eur. J. 2008, 14, 919.
(10) "Mechanism of Metal Halide-Promoted Mukaiyama Aldol Reactions", C.T. Wong and M.W. Wong, J. Org. Chem. 2007, 72, 1425.
(11) "Reaction of the Radical Pair NO2• and CO3•– on 2-[6-(4′-Amino)phenoxy-3H-xanthen-3-on- 9-yl]benzoic Acid (APF)", A.M. Mak, M. Whiteman and M.W. Wong, J. Phys. Chem. A, 2007, 111, 8202.
(12) "Structures and Vibrational Spectra of the Sulfur-Rich Oxides SnO (n = 4-9). The Importance of p*-p* Interaction", M.W. Wong, Y. Steudel and R. Steudel, Chem. Eur. J. 2007, 13, 502.
(13) "Saturated Hydrocarbon-Benzene Complexes: A Theoretical Study of Cooperative CH/p Interaction", Ran J. and M.W. Wong, J. Phys. Chem. A 2006, 110, 9702.
(14) "Structures of the Trisulfur Oxides S3O and S3O+: Branched Rings, not Open Chains", M.W. Wong and R. Steudel, Chem. Commun. 2005, 3712.
(15) "On the Roles of C-H….O=S and p-stacking Interactions in 2-Bromoacrolein Complex with N-tosyl-(S)-tryptophan Derived Oxazaborolidinone Catalyst", M.W. Wong, J. Org. Chem. 2005, 70, 5487.
(16) "Fluoride Ion Receptors Based on Dipyrrolyl Derivatives Bearing Electron-Withdrawing Groups: Synthesis, Optical and Electrochemical Sensing and Computational studies", T. Ghosh, B.G. Maiya, and M.W. Wong, J. Phys. Chem. A 2004, 108, 11249.
(17) "Quantum-Chemical Calculations of Sulfur-Rich Compounds", M.W. Wong, Top. Curr. Chem. 2003,231, 1.
(18) "Atomic Properties of N2O4 Based on Its Experimental Charge Density", M. Messerschmidt, A. Wagner, M.W. Wong, and P. Luger, J. Am. Chem. Soc. 2002, 124, 732.
(19) "Prediction of a Metastable Helium Compound: HHeF", M.W. Wong, J. Am. Chem. Soc. 2000, 122, 6289.
HIGHLY CITED PAPERS
(1) "Solvent Effects. 1. The Mediation of Electrostatic Effects by Solvents", M.W. Wong, M.J. Frisch and K.B. Wiberg, J. Am. Chem. Soc. 1991, 113, 4776. [955 citations]
(2) "Vibrational Frequency Prediction Using Density Functional Theory", M.W. Wong, Chem. Phys. Lett.,1996, 256, 391. [850 citations]
(3) Scaling Factors for Obtaining Fundamental Vibrational Frequencies and Zero-Point Energies from HF/6-31G* and MP2/6-31G*
Harmonic Frequencies", J.A. Pople, A.P. Scott, M.W. Wong and L. Radom, Isr. J. Chem. 1993, 113, 345. [767 citations]
(4) "Solvents Effects. 3. Tautomeric Equilibria of Formamide and 2-Pyridone in the Gas Phase and Solution. An Ab Initio SCRF Study", M.W. Wong, K.B. Wiberg and M.J. Frisch, J. Am. Chem. Soc. 1992,114, 1645. [521 citations]
(5) "Hartree–Fock Second Derivatives and Electric Field Properties in a Solvent Reaction Field: Theory and Application", M.W. Wong, K.B. Wiberg and M.J. Frisch, J. Chem. Phys. 1991, 95, 8991. [369 citations]
(2) "Vibrational Frequency Prediction Using Density Functional Theory", M.W. Wong, Chem. Phys. Lett.,1996, 256, 391. [850 citations]
(3) Scaling Factors for Obtaining Fundamental Vibrational Frequencies and Zero-Point Energies from HF/6-31G* and MP2/6-31G*
Harmonic Frequencies", J.A. Pople, A.P. Scott, M.W. Wong and L. Radom, Isr. J. Chem. 1993, 113, 345. [767 citations]
(4) "Solvents Effects. 3. Tautomeric Equilibria of Formamide and 2-Pyridone in the Gas Phase and Solution. An Ab Initio SCRF Study", M.W. Wong, K.B. Wiberg and M.J. Frisch, J. Am. Chem. Soc. 1992,114, 1645. [521 citations]
(5) "Hartree–Fock Second Derivatives and Electric Field Properties in a Solvent Reaction Field: Theory and Application", M.W. Wong, K.B. Wiberg and M.J. Frisch, J. Chem. Phys. 1991, 95, 8991. [369 citations]